前言:想要寫出一篇令人眼前一亮的文章嗎?我們特意為您整理了5篇英語(yǔ)諺語(yǔ)帶翻譯范文,相信會(huì)為您的寫作帶來(lái)幫助,發(fā)現(xiàn)更多的寫作思路和靈感。
Early mi stakes are the seeds of future trouble,早期的錯(cuò)誤可以釀成日后的麻煩。
Early sow, early mow.早早栽種,早早收割。
Improve your time and your time will improve you.善用時(shí)間,才會(huì)隨著時(shí)間進(jìn)
In youth the hours are go I den in mature years they are silver, in old age they are leaden.青年時(shí)代是黃金,壯年時(shí)代是白銀,老年時(shí)代是灰錯(cuò)。(leaden:錯(cuò)灰色的).
It is only the idle that are wretched.虛度光陰的人最可憐。
It is the tooth I ess animal that arrives first at the base of the fruit tree, to eat his fill before others arrive,無(wú)牙的動(dòng)物會(huì)先到果樹下,趁其他動(dòng)物未抵達(dá)前先吃。
It is too I ate for a galloping horse to stop at a clip; it is use I ess for a sinking boat to be mended in the middle of a river,馬到懸崖收緩?fù)恚两难a(bǔ)漏遲。(gallop:飛跑,奔跑)。
It is too I ate to cast anchor when the ship is on the rock.錯(cuò)過(guò)時(shí)機(jī)再補(bǔ)救,為時(shí)已晚。
It is too I ate to grieve when the chance is past.錯(cuò)失良機(jī),后悔已遲。
It is too I ate to lock the stable door when the steed is stolen.賊走關(guān)門,為時(shí)已晚。
Early start makes easy stages.事早行,易順?biāo)臁?/p>
Easy come, easy go.來(lái)得容易去得快。//來(lái)得快去得快。
Employ your time well if you meanest to get I e i sure.善用時(shí)間,方有閑日叚。
Every minute counts.分秒必爭(zhēng)。
He that does his turn in time, sits half idle.守時(shí)者能悠哉等待。
He that gains time gains all things.獲得時(shí)間就是獲得一切。
He that has time has life.有時(shí)間,就有生活。
He that rises I ate, must trot all day.起床起得晚,整天忙不完。(trot:小跑 著走,急匆匆地走)
He that will thrive must rise at five,五更起床,百事興旺。
what would you do if you failed? many people may choose to give up. however, the surest way to success is to keep your direction and stick to your goal.
on your way to success, you must keep your direction. it is just like a lamp, guiding you in darkness and helping you overcome obstacles on your way. otherwise, you will easily get lost or hesitate to go ahead.
direction means objectives. you can get nowhere without an objective in life.
you can try to write your objective on paper and make some plans to achieve it. in this way, you will know how to arrange your time and to spend your time properly. and you should also have a belief that you are sure to succeed as long as you keep your direction all the time.
翻譯:
如果失敗了你會(huì)怎么做?很多人可能會(huì)選擇放棄。然而,要想成功,最可靠的方法就是堅(jiān)持你的方向和目標(biāo)。
在通往成功的路上,你必須堅(jiān)持你的方向。它就像一盞燈,在黑暗中為你指路,幫助你度過(guò)難關(guān)。否則,你很容易就會(huì)迷失方向或猶豫不前。
However, what is the dream? What is dream? Dream is looking forward to, and the dream is strong - is fleeting dream you insist on the ideal as their courage and perseverance, are you responsible for their own highest level. But ask yourself, how many of us to accomplish his original dream in mind?
Our dream is a simple belief, is a future and life of their own responsibility. Perhaps, is the Youth
grand ambitions; perhaps, is the adolescent confusion and impulsive; maybe just a plain desire, desire applause, eager for success. Countless "may," innumerable "hope" because of our youthful full of miracles, large and small dreams in our hearts, in every corner of life filled with fragrance.
Only the ideal but no effort is useless. If you want to be a teacher, you should to study hard. If you want to be a player, you should do more exercises. If you want to become a businessman, he should learn to get along with people. For example, my wish is to be a famous writer grew up, because I really love writing, so from now on, I should read more, more accumulate knowledge, and strive to improve writing level. No pains, no gains, because my efforts, so my article was punished in many newspapers , and in many composition contest, I see the success I'm happy, so, struggle is the bridge to the ideal.
Yes, my dream. to give my famliy a warm, give my friend happy. Yes, my dream. The podium from the first station began his love this place, started from the first published an article looking forward to the world of words, decided to stay here from the beginning, stick to bottom of my heart desire.
Years in our faces no matter how many additional traces, no matter how much things to us across the chest wounds, as long as we have the right to breathe, to have a passion for remodeling dreams! Oxygen to survive as long as we have to have the courage to create a passion!
Choose to continue, select the value, select the achievements of the passion of life, the brave hearts of the initial dream of success!
海闊憑魚躍,天高任鳥飛。每個(gè)人都懷揣著一個(gè)屬于自己的夢(mèng)想。
然而,什么是夢(mèng)?什么又是夢(mèng)想?夢(mèng)是期待,而夢(mèng)想是堅(jiān)強(qiáng)--是你把飄渺的夢(mèng)堅(jiān)持作為自己理想的勇氣和執(zhí)著,是你對(duì)自己負(fù)責(zé)的最高境界。但捫心自問(wèn),我們有多少人能夠成就自己心中最初的夢(mèng)想?
我們的夢(mèng)想,是一個(gè)簡(jiǎn)單的信念,是一份對(duì)自己未來(lái)與生命的責(zé)任。也許,是二十歲的豪情壯志;也許,是青春期的迷茫與沖動(dòng);也許只是一份平淡的渴望,渴望掌聲,渴望成功。無(wú)數(shù)的“可能”,無(wú)數(shù)的“希望”,因?yàn)槲覀兊那啻簹q月充滿奇跡,我們心中大大小小的夢(mèng),在生活的每一個(gè)角落里芬芳彌漫。
是的,我的夢(mèng)想。一份從一而終的守望--給我的學(xué)生希望,給我的讀者溫暖,給我的愛人幸福。是的,我的夢(mèng)想。從第一次站上講臺(tái)開始迷戀這個(gè)地方,從第一次發(fā)表文章開始憧憬文字世界,從決定留在這里開始,堅(jiān)守心底的渴望。
A, can sense light, can detect light and shade of the surrounding environment;
Second, the eyes see clearly, then you can go faster;
Third, see clearly, can avoid hitting something;
Eyes still has a lot of good, I will give three examples, urge everyone with eyes, please pay attention to your health, don't make the mistake I.
誰(shuí)都知道眼睛是心靈的窗戶,可是誰(shuí)曾經(jīng)注意用眼衛(wèi)生呢?只有視力下降了才追悔莫及,我就是一個(gè)典例。我以前也是不注意我的眼睛導(dǎo)致現(xiàn)在眼睛視力飛速下降。我上網(wǎng)查了一下眼睛的作用,嘿!還真不少。
一、可以感知光線,可以探測(cè)周圍環(huán)境的明暗;
二、眼睛看得清楚,才可以走的更快;
【關(guān)鍵詞】 代謝綜合征;胰島素抵抗;高敏C反應(yīng)蛋白
Study on association of insulin resistance and inflammatory markers in patients with metabolic syndrome
【Abstract】 Objective To investigate the association of insulin resistance (IR) and inflammatory markers in patients with metabolic syndrome (MS),and to explore the role of inflammatory markers in the development of IR in these patients. Methods 31 patients with MS were enrolled into study group,among of them,19 were male,and 12 were female,their average age was (60.8±6.2)y. The control group were made of 20 normal volunteers. The blood levels of high-sensitivity C-reactive protein (Hs-CRP),fibrinogen (Fig),fasting blood glucose (FBG),fasting insulin,and plasma lipids were measured respectively in all the patients and normal subjects,and then,the insulin sensitive index was calculated. Differences of the levels of the fasting blood inflammatory markers between the two groups were compared,and the relative analyses between the Hs-CRP,F(xiàn)ig,blood lipid and ISI were made,respectively.Results Compared with the control group,the ISI of the MS group was significantly lower,but the levels of Hs-CRP and Fig were significantly higher. Multi-linear regression showed that,in MS group,the Hs-CRP,F(xiàn)ig,TG were inversely correlated with ISI,respectively(r=-0.429,P<0.01; r=-0.312,P<0.05; r= -0.219,P<0.05,respectively). Conclusion (1)There are IR and abnomal blood Hs-CRP level in patients with MS.(2)It can be hypothesized that the chronic inflammatory state may be a further feature of the metabolic syndrome.(3)The inflammatory reactions may play an important role in the development of IR in patients with MS.
【Key words】 metabolic syndrome; insulin resistance; high-sensitivity C-reactive protein
有研究表明,血漿高敏C反應(yīng)蛋白不但是炎癥反應(yīng)標(biāo)記物,它還能通過(guò)影響脂蛋白代謝、激活補(bǔ)體、促進(jìn)巨噬細(xì)胞的吞噬功能、刺激單核細(xì)胞表面的組織因子表達(dá)等機(jī)制,參與動(dòng)脈粥樣硬化的發(fā)生、發(fā)展,是動(dòng)脈粥樣硬化發(fā)生的獨(dú)立危險(xiǎn)因素和預(yù)示因子之一[1,2]。代謝綜合征(MS)是一組包括高血壓、高脂血癥、向心性肥胖、糖耐量減低、胰島素抵抗、高胰島素血癥、高游離脂肪酸血癥、高尿酸血癥及微量白蛋白尿、纖溶和凝血功能異常、血栓前狀態(tài)等致動(dòng)脈粥樣硬化危險(xiǎn)因素癥候群。胰島素抵抗可能是代謝綜合征的主要發(fā)病機(jī)制[3,4],而胰島素抵抗發(fā)生的原因目前尚不清楚。代謝綜合征患者胰島素抵抗與炎癥反應(yīng)標(biāo)記物變化之間的關(guān)系研究報(bào)道較少。本研究應(yīng)用靈敏度較高的免疫比濁法測(cè)定血漿高敏C反應(yīng)蛋白水平,以探討代謝綜合征患者血漿高敏C反應(yīng)蛋白水平與胰島素抵抗之間的關(guān)系。
1 對(duì)象與方法
1.1 觀察對(duì)象 選取我院2002年2月~2004年2月門診或住院代謝綜合征患者31例,男19例,女12例,平均年齡(60.8±6.2)歲。另外,在我院體檢的健康者,經(jīng)檢查未發(fā)現(xiàn)異常者,作為正常對(duì)照組(20例),年齡、性別與代謝綜合征組患者匹配。代謝綜合征組(MS)的診斷標(biāo)準(zhǔn)[5]:患者具備以下4項(xiàng)組成成分中3項(xiàng)或全部,就可以診斷代謝綜合征: (1)超重和/或肥胖:體重指數(shù)(BMI)≥25kg/m2;(2)高血糖:空腹血糖≥6.1mmol/L及/或餐后2h血糖≥7.8mmol/L,及/或已確診為糖尿病并治療者;(3)高血壓:收縮壓/舒張壓≥140/90mmHg,及/或已確診為高血壓并治療者;(4)血脂紊亂:空腹血甘油三酯(TG)≥1.7mmol/L,及/或空腹血高密度脂蛋白膽固醇(HDL-C)<0.9 mmol/L(男)或<1.0 mmol/L(女)。所有入選者均經(jīng)詢問(wèn)病史,測(cè)空腹及OGTT服糖后2h血糖證實(shí),排除2型糖尿??;通過(guò)詳詢病史、體格檢查、常規(guī)生化、心電圖檢查排除繼發(fā)性高血壓和心、腦、腎及肝臟等器官的嚴(yán)重并發(fā)癥;排除影響脂質(zhì)代謝的垂體、甲狀腺等內(nèi)分泌疾病及免疫性和腫瘤性疾??;既往未經(jīng)調(diào)脂、降糖、減肥藥治療;抽血前24h未飲酒,未做劇烈運(yùn)動(dòng)。
1.2 研究方法 研究對(duì)象禁食12h后于次日清晨空腹采集靜脈血,分離血清??崭寡?FBG)采用葡萄糖氧化酶法測(cè)定;纖維蛋白原(fibrinogen,F(xiàn)ig)采用比濁法測(cè)定;采用酶法在Backman公司全自動(dòng)生化儀上測(cè)定甘油三脂(TG)、總膽固醇(TC)的濃度;清除法測(cè)血清高密度脂蛋白膽固醇(HDL-C)濃度。按Friedewald 公式計(jì)算血清低密度脂蛋白膽固醇(LDL-C)濃度: LDL- C (mmol/L)=TC- HDL- C -TG/2.2(當(dāng)TG
1.3 統(tǒng)計(jì)學(xué)方法 用SPSS 10.0統(tǒng)計(jì)軟件進(jìn)行分析。計(jì)量資料數(shù)據(jù)以均數(shù)±標(biāo)準(zhǔn)差(x±s)來(lái)表示。主要檢測(cè)指標(biāo)均進(jìn)行正態(tài)性檢驗(yàn)。某些偏態(tài)分布計(jì)量資料經(jīng)對(duì)數(shù)轉(zhuǎn)換后達(dá)到近似正態(tài)分布,再進(jìn)行統(tǒng)計(jì)分析。如ISI在分析時(shí)即取其自然對(duì)數(shù)值Ln[1/(FBG×FINS)][4]。兩組之間比較用t檢驗(yàn),相關(guān)趨勢(shì)變量進(jìn)行直線相關(guān)檢驗(yàn)。采用雙側(cè)P值
2 結(jié)果
2.1 兩組炎癥反應(yīng)標(biāo)志物水平和胰島素敏感性指數(shù)比較 代謝綜合征組的ISI較正常健康對(duì)照組明顯下降(P<0.05);血漿高敏C反應(yīng)蛋白、纖維蛋白原水平等明顯升高(P<0.05)。見表1。 表1 兩組炎癥反應(yīng)標(biāo)志物水平和胰島素敏感性指數(shù)比較結(jié)果注:與對(duì)照組比較,*P<0.05,**P<0.01
2.2 兩組血脂指標(biāo)情況比較 見表2。表2 兩組血脂情況比較
2.3 MS組炎癥標(biāo)志物及血脂水平間單因素相關(guān)分析結(jié)果 在MS組,以ISI為因變量,以Fig、Hs-CRP、TC、TG、HDL、LDL、ApoA、ApoB為自變量,分別進(jìn)行直線相關(guān)分析,結(jié)果:ISI與HDL呈正相關(guān),與Fig,Hs-CRP呈負(fù)相關(guān),與TG、TC、LDL、ApoA、ApoB等無(wú)相關(guān)。見表3。表3 ISI與MS組炎癥標(biāo)志物及血脂水平間單因素相關(guān)分析結(jié)果
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3 討論
代謝綜合征作為一種重要的疾病實(shí)體,它與糖尿病、冠心病有著極為密切的聯(lián)系,已成為預(yù)防糖尿病和冠心病的重點(diǎn)對(duì)象。本研究表明,代謝綜合征患者組胰島素敏感性指數(shù)明顯降低,說(shuō)明代謝綜合征患者存在著胰島素抵抗。胰島素抵抗是指一定量的胰島素產(chǎn)生生物學(xué)效應(yīng)低于預(yù)計(jì)正常水平,即胰島素在促進(jìn)葡萄糖攝取及利用方面受損。大量證據(jù)[4]表明:胰島素抵抗可能是血脂代謝異常、高胰島素血癥等代謝綜合征成分的共同發(fā)病基礎(chǔ),是冠心病、糖尿病發(fā)生、發(fā)展的重要危險(xiǎn)因素。而胰島素抵抗發(fā)生的原因目前尚不清楚。慢性炎癥是動(dòng)脈粥樣硬化發(fā)生、發(fā)展的一個(gè)重要危險(xiǎn)因素和組成部分[7]。Hs-CRP是慢性炎癥的一個(gè)重要標(biāo)志物,它是由Tillett等發(fā)現(xiàn)的能和肺炎鏈球菌細(xì)胞壁C多糖結(jié)合的蛋白質(zhì),也是一種炎癥時(shí)在細(xì)胞因子如IL-6誘導(dǎo)下,由人體肝臟合成和分泌的一種典型的急性期反應(yīng)蛋白。血漿中Hs-CRP濃度在急性心肌梗死、創(chuàng)傷、感染、炎癥、手術(shù)、腫瘤浸潤(rùn)等情況下迅速、顯著地增高。它與人類IgGl重鏈的CH3區(qū)、補(bǔ)體C1及某些HLA抗原的氨基酸序列有相似之處,具有與IgG和補(bǔ)體相似的調(diào)理和凝集作用,能促進(jìn)巨噬細(xì)胞的吞噬功能,還具有刺激單核細(xì)胞表面的組織因子表達(dá)及其他免疫調(diào)節(jié)功能等。Hs-CRP作為一種經(jīng)典的急性時(shí)相蛋白,臨床上主要是將其作為判斷炎癥產(chǎn)生、消退的指標(biāo)而進(jìn)行檢測(cè),其水平增高是體內(nèi)炎癥的敏感指標(biāo)。但是近年來(lái),Hs-CRP在動(dòng)脈粥樣硬化(AS)疾病方面的應(yīng)用成為一個(gè)新的熱點(diǎn),有學(xué)者認(rèn)為Hs-CRP是一個(gè)被低估而未被充分利用的臨床指標(biāo),是心血管疾病的獨(dú)立危險(xiǎn)因子[8]。因?yàn)?,增高的Hs-CRP 除了作為機(jī)體炎癥反應(yīng)的標(biāo)志外,還可能通過(guò)激活單核細(xì)胞、粒細(xì)胞、補(bǔ)體系統(tǒng)以及與粘附分子相互作用,造成血管內(nèi)膜損傷而促進(jìn)動(dòng)脈粥樣硬化的發(fā)生發(fā)展。我們通過(guò)對(duì)慢性炎癥重要標(biāo)志物Hs-CRP在代謝綜合征患者的變化及胰島素抵抗發(fā)生原因的探討,發(fā)現(xiàn)代謝綜合征患者Hs-CRP水平顯著高于對(duì)照組,提示代謝綜合征存在炎癥反應(yīng),即代謝綜合征可能是一種慢性炎癥。相關(guān)分析顯示Hs-CRP與ISI之間存在顯著相關(guān)性,提示代謝綜合征患者Hs-CRP升高與胰島素抵抗之間存在密切關(guān)系。Pickup等的研究發(fā)現(xiàn)有胰島素抵抗表現(xiàn)的2型糖尿病患者與無(wú)明顯胰島素抵抗表現(xiàn)的2型糖尿病患者血清Hs-CRP水平具有顯著差異,提示胰島素抵抗可能是2型糖尿病Hs-CRP增高的主要因素。實(shí)驗(yàn)表明,作為炎癥指標(biāo)的Hs-CRP與巨噬細(xì)胞、平滑肌細(xì)胞和內(nèi)皮細(xì)胞的活化、增殖密切相關(guān),這種Hs-CRP與胰島素抵抗的相關(guān)性可能是代謝綜合征患者易形成冠心病的原因之一。
同Hs-CRP一樣,血漿Fig也是一種急性相反應(yīng)蛋白,是慢性炎癥的標(biāo)志物之一[9]。本研究發(fā)現(xiàn)代謝綜合征組Fig水平高于對(duì)照組,進(jìn)一步說(shuō)明了代謝綜合征可能是一種慢性炎癥。近年來(lái),大量臨床和流行病學(xué)研究資料亦證實(shí)了血漿Fig水平增高是冠心病的獨(dú)立危險(xiǎn)因子。Fig及其降解產(chǎn)物能刺激血管平滑肌細(xì)胞增生、遷移;增加血液的粘稠度,減緩血液流動(dòng),加速動(dòng)脈粥樣硬化損傷,從而可能參與動(dòng)脈粥樣硬化的病理過(guò)程的初始階段[10]。因此,代謝綜合征患者除了控制血糖、血脂、改善胰島素抵抗和血壓等危險(xiǎn)因素以外,臨床上還應(yīng)克服或減輕代謝綜合征患者的慢性炎癥狀態(tài),即降低Hs-CRP及Fig水平,以防止代謝綜合征患者心腦血管事件等并發(fā)病的發(fā)生。本研究由于樣本量小,要確切闡述代謝綜合征患者胰島素抵抗與Hs-CRP及其他炎癥因子的內(nèi)在聯(lián)系及機(jī)制,尚有待進(jìn)一步研究。
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